Antidepressant-like Effects of Neuropeptide SF (NPSF)

Masaru Tanaka, Gyula Telegdy

Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse roles in central nervous system. Little is know about the effects of NPSF on brain functions. Antidepressant-like effect of NPSF was studied in modified mice FST. NPSF showed the antidepressant-like effects by decreasing the immobility time and increasing the climbing and swimming time. Furthermore, the involvement of the adrenergic, serotonergic, cholinergic or dopaminergic receptors in the antidepressant-like effect ofNPSF was studied in modified mice FST. Mice were pretreated with a non-selective α-adrenergic receptor antagonist phenoxybenzamine, a β-adrenergic receptor antagonist,propranolol, a non-selective5-HT2serotonergic receptor antagonist,cyproheptadine, nonselective muscarinic acetylcholine receptor antagonist, atropine, or D2, D3, D4 dopamine receptor antagonist, haloperidol. The present results confirmed that the antidepressant-like effect ofNPSF is mediated, at least in part, by an interaction of the α-adrenergic, 5-HT2serotonergic, muscarinic acetylcholine receptors and D2, D3, D4 dopamine receptor in a modified mouse FST.