Association Of A HER2 Ile655Val (Rs1136201) Polymorphism in Breast Cancer in A Mexican Population

Dalia Ivette Carrillo-Moreno, Luis Eduardo Figuera, Maria Teresa Magana-Torres, Guillermo Zuniga-Gonzalez, Ana María Puebla-Perez, Martha Patricia Gallegos-Arreola

EGFR (epidermal growth factor receptor) has tyrosine kinase activity and plays an important role in processing carcinogens. Data on the HER2 Ile655Val polymorphism have revealed associations with cancer, suggesting that this polymorphism contributes to tumor promotion in breast cancer (BC). We examined the role of the HER2 Ile655Val genotype by comparing the genotypes of 225 healthy Mexican women with 400 Mexican women with BC. The genotype frequencies observed in the controls and patients with BC were 14.6 and 21%, respectively, for the A/G (Iso/Val) genotype. The obtained odds ratio (OR) was 1.5, with a 95% confidence interval (CI) from 1.01-2.4, P = 0.04. The association was also evident upon analysis of the distributions from the A/G-G/G genotype in patients with nulliparity and non-chemotherapy response who were positive for HER2 tumor expression (OR 2.5, 95%CI = 1.06-7.78, P = 0.032). This study suggests that the A/G genotype HER2 Ile655Val polymorphism is associated with BC susceptibility in the Mexican population.