Gene Expression Signatures of Ductal Breast Carcinoma Shows Differentially Expression of Cell Cycle, Proliferation and Apoptosis Related Genes

Lokman Varisli

Breast cancer is one of the most common malignant diseases among women in western countries. Ductal carcinoma of the breast is a pre-invasive malignant lesion that is curable. However, undetected or untreated tumors can progress to invasive breast cancer. Therefore, understanding of molecular changes in this tumor and determining of diagnostic and prognostic biomarkers will be valuable for early diagnosis and predict of prognosis in this disease. In this study, we investigated differentially expressed genes in ductal carcinoma of breast. Moreover, we also investigated probable mechanisms that abrogated in these lesions. The results have shown that there are 96 upregulated and 110 downregulated gene in ductal breast cancer compared normal breast. Analyzing of this gene list revealed that upregulated genes are significantly enriched cell cycle term. However, downregulated genes are enriched regulation of cell proliferation and apoptosis terms.