The Effect of Zinc Treatment with The Prostaglandin (PGF2α) and TNF-α Level in Dysmenorrhea Patients

Setia Nisa, Vaulinne Basyir, Afriwardi

Background: The aim of the study determine the effect of zinc treatment with the prostaglandin (PGF2α) and TNF-α level in dysmenorrhea patients. Methods: The study was conducted using a quasi experimental with pre-post test group design. The study was conducted at Piala Sakti School of Health Pariaman, West Sumatera Province, Indonesia from April-Mei 2018. The population in this study was teenagers with dysmenorrhea, sample size 22 people. Sampling technique with convenience sampling. This study used groups before treatment and after treatment of zinc treatment in the same group with a dose of 30 mg/ day for 3 days before pain. Test the normality of data by Shapiro-Wilk test and hypothesis test using paired t test. A two-tailed P-value of <0.05 was considered statistically significant. Results: The results showed that the mean of prostaglandin level before treatment was 413.04 ± 11.52 pg/ ml after treatment 215.71 ± 8.13 pg/ ml and the mean of TNF-α level before treatment was 412.82 ± 10.90 ng/ L which after treatment 215.90 ± 10.77 ng/ L, the analysis used was to determine the effect of zinc treatment with PGF2 α and TNF-α levels, using dependent T test, from this analysis the results were obtained prostaglandin levels (PGF2α) with P = 0.001 and TNF-α with p = 0.001 (p <0.05) Conclusion: The conclusion of this study confirmed there was an effect of zinc treatment with the prostaglandin (PGF2α) and TNF-α in dysmenorrhea patients.

https://doi.org/10.31871/WJRR.8.1.9