The Relationship Vitamin C Level and MMP-2 Serum with Premature Rupture of Membranes and Normal Pregnancy

Ika Yulia Darma, Arni Amir, Vaulinne Basyir

Background: One of the important problems in obstetrics is premature rupture of membranes. Incidence of premature rupture of membranes caused by multifactorial, including the factors of infection and nutrients of pregnant women that affect the elasticity of membranes. The aim of the study to investigate the relationship vitamin C level and MMP-2 serum with premature rupture of membranes and normal pregnancy. Methods: This research is cross sectional comparative study design. The research is in the Midwife Room of Bhayangkara Hospital, dr. Reksodiwiryo and dr. Rasidin Hospital Padang in September - October 2017. The population in this study were pregnant women with early rupture of membranes and all women with normal pregnancy (gestational age ≥ 37-42 weeks) and sample size 58 people in two groups. Sampling technique with consecutive sampling. The examination of vitamin C and MMP-2 levels was performed in Biomedical Laboratory of Faculty of Medicine, Universitas Andalas by ELISA method. Test of data normality with Shapiro-Wilk test and independent sample T test and Pearson correlation for hyphotesis. Results: The results showed that mean of vitamin C level in premature rupture of membranes was 0.53 ± 0.09 mg/dl, and 0.58 ± 0.08 mg/dl in normal pregnancy (p <0.05). The mean of MMP-2 level in premature rupture of membranes was 35.17 ± 2.23 ng/ml, and 33.27 ± 0.82 ng/ml in normal pregnancy (p <0.05). There was no relationship between vitamin C and MMP-2 levels with premature rupture of membranes and normal pregnancy (p> 0.05). Conclusion: The conclusion of this study there were mean difference of vitamin C and MMP-2 levels in premature rupture of membranes and normal pregnancy. However, there was no relationship between vitamin C and MMP-2 levels in premature rupture of membranes and normal pregnancy

https://doi.org/10.31871/WJRR.7.4.8